Injectable thermosensitive composite hydrogels based on degradable

poly(N-isopropylacrylamide) poly(ethylene glycol) triblock copolymers

- THERMOGELS -

Project number: PN-II-ID-PCE-2012-4-0082

Project funding: 957.375 RON

Project duration: 37 months (September 2, 2013 September 30, 2016)

Funding agency: CNCS UEFISCDI

Contract number: 37/02.09.2013

 

1. PROJECT TEAM

     Professor Mircea Teodorescu project director
     Dr. Paul Stanescu Reader
     Maria Andrei M.S./Ph.D. student
     Gabriel Turturica M.S. student
     Florin Maris technical assistance
     Ileana Duta technical assistance


2. PROJECT MOTIVATION

3. PROJECT SUMMARY

4. EXPECTED RESULTS


5. OBJECTIVES
      - Objectives 2013
      - Objectives 2014
      - Objectives 2015
      - Objectives 2016


6. RESEARCH REPORTS
      - Research Report 2013
      - Research Report 2014
      - Research Report 2015
      - Research Report 2016


7. RESULTS DISSEMINATION

      - Communications
            - Novel Sodium Alginate – Poly(N-isopropylacrylamide) Thermoreversible Injectable Hydrogels with Semi-Interpenetrating Network Structure - PRIOCHEM 2014 - poster
           
- Thermal Degradation of Poly(N-Isopropylacrylamide-co-5,6-Benzo-2-Methylene-1,3-Dioxepane) Statistical Copolymers: a Kinetic Analysis - PRIOCHEM 2014 - poster
            - Degradable poly(N-isopropylacrylamide)-poly(ethylene glycol)-poly(N-isopropylacrylamide) triblock copolymers: synthesis and thermogelation properties of aqueous solutions 11 th International Symposium on Frontiers in Biomedical Polymers, July 8 th -11 th , 2015, Riva del Garda, Italy poster
            - The effect of dextran addition upon the thermogelation and drug release properties of poly(N-isopropylacrylamide) injectable hydrogels PRIOCHEM 2015 - poster
            - Degradable injectable thermosensitive hydrogels from ABA triblock copolymers of poly(N-isopropylacrylamide) (A) and poly(ethylene glycol) (B) - EMN Meeting on Hydrogel Materials 2016, May 9-13, 2016, Singapore invited talk
            - Poly(N-Isopropylacrylamide)/dextran aqueous solutions as thermosensitive injectable hydrogels: thermogelation and drug release properties - International Congress on Biomaterials and Biosensors (BIOMATSEN 2016), June 1-3, 2016, Istanbul, Turkey - poster
            - Thermoreversible hydrogels with hydrolytic degradability obtained from novel poly(N-isopropylacrylamide-co-ester)-b-poly(ethylene glycol)-b-poly(N-isopropylacrylamide-co-ester) triblock copolymers - 6th International Colloids Conference, June 19-22, 2016, Berlin, Germany - poster

      - Articles
            - P. O. Stanescu, G. Turturica, M. Andrei, C. Draghici, D. M. Vuluga, A. Zaharia, A. Sârbu, M. Teodorescu, Kinetic study upon the thermal degradation of poly(N-isopropylacrylamide-co-5,6-benzo-2-methylene-1,3-dioxepane) statistical copolymers, Materiale Plastice, 52(2), 193-197 (2015)
            - M. Teodorescu, M. Andrei, G. Turturica, P. O. Stanescu, A. Zaharia, A. Sârbu, Novel thermoreversible injectable hydrogel formulations based on sodium alginate and poly(N-isopropylacrylamide), International Journal of Polymeric Materials and Polymeric Biomaterials 64(15), 763-771 (2015)
            - G. Turturica, M. Andrei, P. O. Stanescu, C. Draghici, D. M. Vuluga, A. Zaharia, A. Sârbu, M. Teodorescu, ABA triblock copolymers of poly(N-isopropylacrylamide-co-5,6-benzo-2-methylene -1,3-dioxepane) (A) and poly(ethylene glycol) (B): synthesis and thermogelation and degradation properties in aqueous solutions, Colloid and Polymer Science 294(4), 743-753 (2016)
            - M. Andrei, G. Turturica, P. O. Stanescu, M. Teodorescu, Thermosensitive injectable hydrogels from poly(N-isopropylacrylamide) dextran aqueous solutions: thermogelation and drug release properties, Soft Materials 14(3), 162-169 (2016)

            - M. Andrei, P. O. Stanescu, C. Draghici, M. Teodorescu, Degradable thermosensitive injectable hydrogels with composite structure from aqueous solutions of poly(N-isopropylacrylamide-co-5,6-benzo-2-methylene -1,3-dioxepane) - poly(ethylene glycol) triblock copolymers and biopolymers, submitted
            - M. Andrei, C. Draghici, M. Teodorescu, Gelation properties of the aqueous solutions of hydrolytically degradable thermosensitive poly(n-isopropylacrylamide-co-5,6-benzo-2-methylene-1,3-dioxepane) copolymers, submitted